PBA symptoms are prevalent in various underlying neurologic conditions1

The prevalence of PBA in the US is approximately 2 million, among patients with underlying conditionsa-d

In PRISM (N=5290), a multicenter registry, PBA symptoms were reported at rates between 26%-52% by patients (or their caregivers) with any one of 6 neurologic conditions, based on a validated screening toola,1

PRESENCE OF PBA SYMPTOMS IN COMMON NEUROLOGIC CONDITIONSb,1

Presence of PBA symptoms in common neurologic conditions
Study Description
 

PRISM, a multicenter (173-site) study, enrolled 5290 patients with one of 6 conditions: Alzheimer's disease (AD), stroke, traumatic brain injury (TBI), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), or multiple sclerosis (MS). Patients (or their caregivers) completed the Center for Neurologic Study-Lability Scale (CNS-LS)—a 7-item questionnaire that provides a quantitative measure of the perceived frequency of PBA episodes—and an 11-point scale measuring impact of the neurologic condition on the patient's quality of life.1

Based on a Harris poll of patients and their families (N=2318), an estimated 37%of Americans with any of these 6 common neurologic conditions have symptoms suggestive of PBAa,b,2

The importance of screening for PBA

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WATCH DR FISHER DISCUSS THE PREVALENCE OF PBA IN YOUR PRACTICE <span class="timecode">(0:58)</span>

Use this tool to screen for PBA in your practice

aThe CNS-LS was validated as a PBA screening tool in ALS and MS populations. A CNS-LS ≥13 may suggest PBA but does not confer a PBA diagnosis.1,3-5
bAs determined by a score ≥13 on the CNS-LS applied to population data for specific neurologic conditions.2
cA more restrictive definition was also evaluated using a CNS-LS ≥21, consistent with the mean baseline CNS-LS score for patients participating in PBA clinical trials.4,5
dThe number of Americans with PBA symptoms was estimated from survey data and applied to the following US prevalence estimates for neurologic conditions: PD, 1,000,000; AD/dementia, 6,800,000; stroke, 5,400,000; ALS, 30,000; MS, 400,000; TBI, 5,300,000.2

Prevalence of PBA vs other major conditions2,6-8

US PREVALENCE
US prevalence

HIV=human immunodeficiency virus; PBA=pseudobulbar affect;
RA=rheumatoid arthritis; T1D=type 1 diabetes; M=million.  

PBA may be more prevalent than you think