PBA symptoms are common43

  • The estimated prevalence of PBA in the US is approximately 2 milliona-d,43
  • An estimated 7 million people with neurologic conditions have symptoms suggestive of PBAa-d,43

Presence of PBA symptoms in common neurologic conditions
(based on PRISM registry: n=5290; 173 sites)b,c,4

Presence of PBA symptoms in common neurologic conditions
53% of patients with a CNS-LS score ≥13 in the PRISM study were taking psychotropic medications versus 35% of patients with a CNS-LS score <13e,4
• In a 120-resident nursing home, as many as 31 residents may have symptoms suggestive of PBA that may merit further assessmentf,4,9


aWhen considering patients with any of the 6 common neurologic conditions associated with PBA, it is estimated that 37%, or an estimated 7 million Americans, have symptoms suggestive of PBA as determined by a score ≥13 on the Center for Neurologic Study-Lability Scale (CNS-LS) applied to population data for specific neurologic conditions.43
bThe CNS-LS was validated as a PBA screening tool in amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) populations. A CNS-LS ≥13 may suggest PBA but does not confer a PBA diagnosis.29,36,37
cA more restrictive definition was also evaluated using a CNS-LS ≥21, consistent with the mean baseline CNS-LS score for patients participating in PBA clinical trials.36,37
dThe number of Americans with PBA symptoms was estimated from survey data and applied to the following US prevalence estimates for neurologic conditions: PD, 1,000,000; AD/dementia, 6,800,000; stroke, 5,400,000; ALS, 30,000; MS, 400,000; TBI, 5,300,000.43
eTherapeutic rationale for use of psychotropic medications was not captured. Psychotropic medication included antidepressants and antipsychotics.
fProjection is based on prevalence numbers from the PRISM study for CNS-LS ≥13 and the Centers for Medicaid and Medicare Services Minimum Data Set resident report.4

Prevalence of PBA vs other major conditions2,7,8,43

US prevalence
US prevalence

HIV=human immunodeficiency virus; PBA=pseudobulbar affect;
RA=rheumatoid arthritis; T1D=type 1 diabetes; M=million.  

PBA may be more prevalent than you think